Social entrepreneurship has emerged as a transformative force in addressing global challenges such as poverty, inequality, environmental degradation, and inadequate access to healthcare and education. By integrating business principles with a mission-driven approach, social entrepreneurs create innovative and sustainable solutions to pressing social and economic issues. This paper explores the role of social entrepreneurship in solving global challenges, examining key strategies, impact measurement frameworks, and successful case studies from different regions. The discussion highlights how social enterprises leverage technology, partnerships, and innovative financial models to drive scalable and sustainable change. Furthermore, it addresses the challenges faced by social entrepreneurs, including funding constraints, regulatory hurdles, and scalability issues. The study concludes that fostering a supportive ecosystem through policy interventions, impact investment, and cross-sector collaboration is crucial for enhancing the effectiveness and reach of social entrepreneurship in tackling global challenges.