Women-led enterprises form a vital part of India’s MSME sector, constituting 20.37% of the total and employing 23.3% of the workforce. In Rajasthan alone, over 4.8 lakh MSMEs are reported, with South-East districts like Kota, Bundi, Baran, and Jhalawar offering a unique lens to study women entrepreneurship. This research explores the key economic and socio-cultural factors influencing the performance of women entrepreneurs in this region. Economically, limited access to credit, low capital investment, poor infrastructure, and inadequate awareness of government schemes hinder growth. Socio-cultural challenges, including traditional gender roles, restricted mobility, and limited family or social support, further constrain their potential. Despite these barriers, many women pursue entrepreneurship driven by ambition and the need for financial independence. The study highlights the need for integrated policy support, financial inclusion, and cultural change to create a more enabling environment for women entrepreneurs in South-East Rajasthan.