Many Natural products and traditional medicines have played a pivotal role in healthcare systems across cultures for centuries. Derived from plants, animals, and microorganisms, natural products serve as a rich source of bioactive compounds with therapeutic potential. Traditional medicine, encompassing practices such as Ayurveda, Traditional Chinese Medicine (TCM), and indigenous healing systems, often relies heavily on these natural substances. Recent scientific advancements have validated many traditional remedies, leading to the discovery of novel drugs and treatments. The integration of ethnopharmacological knowledge with modern research methodologies has enhanced our understanding of the mechanisms, efficacy, and safety of these natural therapies. However, challenges remain in standardization, quality control, and regulatory oversight. As interest in complementary and alternative medicine grows globally, natural products and traditional medicines continue to offer valuable insights for drug discovery, development. holistic health, and sustainable healthcare. Medicinal plants and their bioactive compounds are highlighted for their contributions to managing chronic diseases and emerging health threats, including the COVID-19 pandemic. Recent advances in analytical technologies, omics sciences, and nano-medicine have expanded our understanding and application of traditional remedies. The convergence of traditional wisdom and modern evidence-based medicine holds promise for sustainable, accessible, and holistic health care solutions. Rigorous scientific validation is essential to ensure the safe and effective use of traditional remedies. Keywords: Extracts, ethno-medicine, herbs, tradition. To move modern medical research on natural products forward, researchers face many challenges. Important information about natural products and traditional medicines is buried in huge amounts of documents and data, mixed together with irrelevant or low-quality information. These sources contain active compounds, inactive ones, and substances that may work better together. The first major step, therefore, is to filter out what is unhelpful and keep what truly matters—drawing on the valuable knowledge and experience gained from the use of natural products and traditional medicines. Despite their proven efficacy in many cases, challenges remain, including standardization, quality control, and integration into modern healthcare frameworks. Natural products offer a vast and chemically diverse reservoir of bioactive compounds. Traditional medicine, grounded in indigenous knowledge and cultural practices, has historically relied on these natural substances for the prevention and treatment of various elements. It highlights the importance of bridging traditional knowledge with modern scientific validation to harness the full potential of natural products for drug discovery, public health, and sustainable development.