This study investigates the impact of job stress and job insecurity on job performance in Micro, Small, and Medium Enterprises (MSMEs), focusing on the mediating roles of organizational trust and employee motivation. MSMEs, crucial for economic growth and employment, face significant challenges that affect employee well-being and performance. The study finds that both job stress and job insecurity negatively influence job performance, while organizational trust and employee motivation serve as important mediators in these relationships. By fostering a culture of trust and enhancing employee motivation, MSMEs can mitigate the negative effects of stress and insecurity, ultimately improving job performance and overall organizational success. The research provides insights for MSME leaders to develop effective strategies that promote employee engagement, productivity, and a healthier work environment.